Textbook of Personalized Medicine PDF reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics.
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Author: Kewal K. Jain, MD, FRACS, FFPM
Jain PharmaBiotech, Basel, Switzerland
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Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available.
Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
Considerable advances have taken place in technologies used for advancing person-alized medicine, and it is increasingly applied in clinical use. This has required expansion and revision of some parts of the first edition published in 2009. The style has been maintained due to the positive feedback of readers, including scientists, pharmacists, physicians, and lay persons interested in this topic. The book provides a concise and comprehensive source of reference for those involved in healthcare management, planning, and politics. As a single author book, it avoids the overlaps and missing areas frequently found in multiauthor books. Moreover, the time to publication is reduced by avoiding the long delays of numerous authors who do not keep the deadlines.
The book includes 700 references selected from thousands of publications during the past decade and appended at the end of each chapter. Some of the references included were prepublication versions at the end of 2014 that will not be formally published until 2015. The text is supplemented by 31 illustrations and 56 tables.
Algorithms are included as a guide to those involved in the management of important diseases where decision making is involved due to the multiple choices available.
Finally, I thank the editorial staff of Springer, particularly Patrick Marton and David Casey, for their help and encouragement in this project.
Kewal K. Jain
Table of Contents- Textbook of Personalized Medicine PDF
1 Basic Aspects . 1
2 Molecular Diagnostics in Personalized Medicine 35
3 Role of Biomarkers in Personalized Medicine 91
4 Pharmacogenetics 99
5 Pharmacogenomics 149
6 Pharmacoproteomics 159
7 Role of Metabolomics in Personalized Medicine 169
8 Non-genomic Factors in the Development of Personalized Medicine 179
9 Personalized Biological Therapies 189
10 Personalized Therapy of Cancer 199
11 Personalized Management of Infectious Diseases 383
12 Personalized Management of Neurological Disorders 409
13 Personalized Management of Psychiatric Disorders 461
14 Personalized Management of Cardiovascular Disorders 479
15 Personalized Management of Pulmonary Disorders 511
16 Personalized Management of Genetic Disorders 529
17 Personalized Approaches to Immune Disorders . 551
18 Personalized Approaches to Miscellaneous Problems in Healthcare 565
19 Personalized Non-pharmacological Therapies 577
20 Development of Personalized Medicine 589
21 Ethical Aspects of Personalized Medicine 655
22 Regulatory Aspects of Personalized Medicine 665
23 Economics of Personalized Medicine 681
24 Future of Personalized Medicine 693
About the author
Kewal K. Jain, MD, FRACS, FFPM
Jain PharmaBiotech, Basel, Switzerland
He is a neurologist/neurosurgeon by training and has been working in the biotechnology/ biopharmaceuticals industry for several years. He received graduate training in both Europe and USA, has held academic positions in several countries, and is a Fellow of the Faculty of Pharmaceutical Medicine of the Royal College of Physicians of UK. Currently, he is a consultant at Jain PharmaBiotech.
He has been working on developing personalized therapy by integrating new technologies in addition to genomics since 1997. His monograph with the title Personalized Medicine published in 1998 was the fi rst treatise on this topic. Over the years, it went through several editions until it evolved into the Textbook of Personalized Medicine , published by Springer in 2009. It was translated into Japanese in 2012 and the current version is the second edition of this book.
Professor Jain’s 452 publications include 25 books (5 as editor + 20 as author) and 50 special reports, which have covered important areas in biotechnology, gene therapy, and biopharmaceuticals. His important recent books include Handbook of Nanomedicine (Springer 2008; Chinese edition, Peking University Press 2011; 2nd ed Springer 2012), Handbook of Biomarkers (Springer 2010), Handbook of Neuroprotection (Springer 2010), Drug-induced Neurological Disorders , 3rd ed (Hogrefe 2011), Applications of Biotechnology in Cardiovascular Disorders (Springer 2011), Applications of Biotechnology in Neurology (Springer 2013), and Applications of Biotechnology in Oncology (Springer 2014). He has edited Applied Neurogenomics (January 2015).